This is an important and timely volume. The history of research in
homocysteine metabolism can be divided into three periods. The
first phase was the exploration of the individual reactions and
metabolites that characterize the transmethylation and
transsulfuration sequences. The former originated with his
description of the biosynthesis of methylpyridine and culminated in
the work of Cantoni and Axelrod. Similarly the finding that insulin
contained cystine was a potent catalyst for the metabolic and
nutritional studies of Rose and du Vigneaud. The description and
the definition of homocystinuria, a rare inherited meta bolic
disorder, marked the beginning of the second historical period.
Where previously there had been few laboratories located largely in
the United States soon there were numerous research groups
representing many nationalities. The more intense focus led to
major advances, both in the laboratory and in the clinics. Studies
of afflicted individuals, when combined with investigations in
experimental animals, provided the basis for a concept of
methionine metabo lism that encompassed both transmethylation and
transsulfuration. The central role of homocysteine was apparent."
General
| Imprint: |
Springer
|
| Country of origin: |
Netherlands |
| Series: |
Developments in Cardiovascular Medicine, 230 |
| Release date: |
December 2010 |
| First published: |
2000 |
| Editors: |
K Robinson
|
| Dimensions: |
229 x 152 x 23mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
448 |
| Edition: |
Softcover reprint of the original 1st ed. 2000 |
| ISBN-13: |
978-90-481-5431-9 |
| Categories: |
Books >
Medicine >
Clinical & internal medicine >
Cardiovascular medicine
|
| LSN: |
90-481-5431-6 |
| Barcode: |
9789048154319 |
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