Since the first edition of Complement in Health and Disease was
published in 1986, significant advances have been made. The cDNAs
for all of the components and some of the receptors have been
cloned and sequenced. The chromosomal localization and the
structural organization of a number of these genes have now been
determined. These advances are now facilitating research into the
structure of the complement proteins, the nature of the complement
deficiency syndromes, the regulation of complement gene expression
and the role of complement in different diseases. This edition
contains contributions from both basic and clinical scientists in a
format which we hope will appeal to both immunologists and
physicians who wish to know more about this fascinating and
important host defence system. The introductory chapter by John
Weiler presents a historical background to research on the
complement system and describes the biochemical events occurring
during activation of the system. In Chapter 2 Alastair Dodds and
Tony Day discuss the phylogeny and evolution of the complement
system. The techniques of protein chemistry and molecular biology
have provided powerful insights into the modular structure of
complement proteins and the evolution of the complement system. The
structure and organisation of the complement genes is described in
Chapter 3 by Ken Reid and Duncan Campbell. This chapter describes
the modular structure of the complement proteins and some of the
mutations which are responsible for deficiencies of individual
components.
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