Tissue engineering has been redefined as "the use of physical,
chemical, biological and engineering processes to control and
direct the aggregate behaviors of cells." This offers tremendous
opportunities for designing in vitro physiological models to study
disease pathogenesis, inventing cell-based therapeutics in clinical
applications and developing novel pharmaceutical methods for
reducing the use of animals in drug testing. However, while using
biomanufacturing processes, cells are subjected to an array of
mechanical forces which may injure it. While experimental studies
have been conducted for specific bio-fabrication systems to
understand cell responses, an engineering model is also needed that
can be used to predict the effect of mechanical forces on cells. A
multi scale modeling approach for the analysis of cell damage in
bioprinted tissue constructs is presented here. The approach
includes analysis of the tissue constructs at a macro scale model,
developing a multi-cellular scale model and a single cell model
wherein the microstructures of the cell like the nucleus and the
cytoplasm have been incorporated.
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