Extrahepatic portal vein obstruction (EHPVO) is an important cause
of noncirrhotic portal hypertension in the developing countries (up
to 30% of all variceal bleeders) and is second to cirrhosis in the
West (up to 5-10%). EHPVO is also the most common cause of upper
gastrointestinal bleeding in children. It accounts for almost 70%
of pediatric patients with portal hypertension. EHPVO occurring in
the pre-pubertal period could result in growth retardation in
around 50% of the children. Reduced portal blood supply to the
liver, resistance to growth hormone function and reduced
insulin-like growth factor has been hypothesized for growth
retardation. This study aimed to find out whether digestive or
endocrine abnormality is responsible for growth retardation in
EHPVO.
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