Elevated intraocular pressure is the most significant risk factor
in glaucoma but the mechanisms of retinal ganglion cell death in
remain incompletely understood. Animal models of glaucoma provide a
way to study the possible pathogenesis of glaucomatous retinal
ganglion cell death and to assess potential neuroprotective
strategies. In this volume, Dr Keith Martin describes in detail how
a trabecular laser glaucoma model can be used to study changes
occuring in the retina and optic nerve of eyes with elevated
intraocular pressure. The possible involvement of retinal glutamate
transporters in glaucoma is explored, hinting at possible new
treatment approaches. Dr Martin goes on to describe in detail the
techniques that led to the first successful use of neurotrophic
factor gene therapy to reduce retinal ganglion cell death in
experimental glaucoma.
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