The molecular era ushered in the cloning of the growth hormone
(GH) gene and the production of unlimited amounts of GH through
recombinant technology. The continuing momentum of research from
basic science to clinical evaluation has brought unprecedented
advances to the understanding of GH biology for the clinical
endocrinologist. Growth Hormone Related Diseases and Therapy: A
Molecular and Physiological Perspective for the Clinician distills
all the new information of relevance to the endocrinologist over
the last 20 years by offering five sections: physiology, molecular
genetics, GH deficiency, acromegaly and pharmacotherapy. The first
section on physiology focuses on GH action.
A review on the structure and function of the GH receptor is
followed by a perspective on the regulatory role of ghrelin on GH
secretion. The second section on genetics covers pituitary function
and adenomas, including new and fascinating information on familial
pituitary adenomas, their genotype and phenotype. The adult GH
deficiency section spans the epidemiology and diagnosis of GH
deficiency with a strong reminder for the clinician that the
transition period represents a critical time of somatic maturation,
which continues for years after cessation of liner growth. The
section on acromegaly focuses on management, giving practical
guides to the value of GH and IGF-1 measurements, the place of
somatostatin analogues and of radiotherapy while reminding the
reader as to why evaluating quality of life is an important part of
management. Finally, the section on GH pharmacology takes the
reader through innovative developments of long-acting GH
formulations with some products on the threshold of clinical use.
This section provides a balanced evidence based review of the
effects of GH supplementation in aging and in sports where recent
data indicates an enhancing effect on a selective aspect of
performance. Growth Hormone Related Diseases and Therapy: A
Molecular and Physiological Perspective for the Clinician
integrates a wealth of information and will prove an invaluable
reference for pediatric endocrinologists, adult endocrinologists,
endocrine scientists and internists interested in the human biology
of GH."
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