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Books > Medicine > Clinical & internal medicine > Paediatric medicine
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Growth Hormone Related Diseases and Therapy - A Molecular and Physiological Perspective for the Clinician (Hardcover, Edition.)
Loot Price: R5,207
Discovery Miles 52 070
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Growth Hormone Related Diseases and Therapy - A Molecular and Physiological Perspective for the Clinician (Hardcover, Edition.)
Series: Contemporary Endocrinology
Expected to ship within 10 - 15 working days
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The molecular era ushered in the cloning of the growth hormone (GH)
gene and the production of unlimited amounts of GH through
recombinant technology. The continuing momentum of research from
basic science to clinical evaluation has brought unprecedented
advances to the understanding of GH biology for the clinical
endocrinologist. Growth Hormone Related Diseases and Therapy: A
Molecular and Physiological Perspective for the Clinician distills
all the new information of relevance to the endocrinologist over
the last 20 years by offering five sections: physiology, molecular
genetics, GH deficiency, acromegaly and pharmacotherapy. The first
section on physiology focuses on GH action. A review on the
structure and function of the GH receptor is followed by a
perspective on the regulatory role of ghrelin on GH secretion. The
second section on genetics covers pituitary function and adenomas,
including new and fascinating information on familial pituitary
adenomas, their genotype and phenotype. The adult GH deficiency
section spans the epidemiology and diagnosis of GH deficiency with
a strong reminder for the clinician that the transition period
represents a critical time of somatic maturation, which continues
for years after cessation of liner growth. The section on
acromegaly focuses on management, giving practical guides to the
value of GH and IGF-1 measurements, the place of somatostatin
analogues and of radiotherapy while reminding the reader as to why
evaluating quality of life is an important part of management.
Finally, the section on GH pharmacology takes the reader through
innovative developments of long-acting GH formulations with some
products on the threshold of clinical use. This section provides a
balanced evidence based review of the effects of GH supplementation
in aging and in sports where recent data indicates an enhancing
effect on a selective aspect of performance. Growth Hormone Related
Diseases and Therapy: A Molecular and Physiological Perspective for
the Clinician integrates a wealth of information and will prove an
invaluable reference for pediatric endocrinologists, adult
endocrinologists, endocrine scientists and internists interested in
the human biology of GH.
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