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Promising Role of Natural products against Alzheimer's Disease (Paperback)
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Promising Role of Natural products against Alzheimer's Disease (Paperback)
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The most well-known type of neurodegenerative dementia is
Alzheimer's disease (AD) in elderly, an age-dependent
neurodegenerative disease, proceeds at stages from mild, moderate
to severe and gradually destroys the brain. Advancing age, age
related diseases such as cardiovascular disease, diabetes, obesity
and cancer, head trauma and exposure to heavy metals such as Al,
cupper, iron and zinc are the major cause for AD. The current study
was designed to explore the potent role of Salvia triloba, Piper
nigrum, Ruta graveolens and Pegenum harmala in management of
neuroinflammatory insults characterizing AD in experimental rat
model. The present study suggested that the studied medicinal plant
extracts have a different degree of potentiality in alleviating AD.
This promising effect was achieved through their powerful
anti-cholinesterase activity, anti-inflammatory property and
anti-apoptotic capacity. The current study represented good
therapeutic approach for intervention against progressive
neurological damage associated with AD.
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