Volume Transmission Revisited describes the mounting evidence that
cells of the central nervous system are able to communicate via a
host of chemical signals that flow through the extracellular space.
Volume transmission (VT) constitutes a novel and complementary
communication system to classical synaptic transmission. The new
modality, which does not require specific connections between
cells, leads to a reconsideration of the spatial relationships of
neurons and glia, brings a new dimension to network modelling and
is relevant to both short term interactions and long term tonic
states of the brain.
The reader will find 29 chapters describing many of the major
discoveries in VT during the last decade.
The most striking feature of this publication is the collecting
together of many compelling examples of the ubiquitous nature of
VT. These point to its increasing relevance from basic neuroscience
research to clinical practice. Those working in other areas will
find numerous invaluable examples of how leading investigators have
gone about assembling evidence for VT.
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