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Recent Advances in NGF and Related Molecules - The Continuum of the NGF "Saga" (Paperback, 1st ed. 2021)
Loot Price: R6,339
Discovery Miles 63 390
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Recent Advances in NGF and Related Molecules - The Continuum of the NGF "Saga" (Paperback, 1st ed. 2021)
Series: Cellular Neuroscience, Neural Circuits and Systems Neuroscience, 1331
Expected to ship within 10 - 15 working days
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More than fifty years after its initial discovery by Rita Levi
Montalcini and Stanley Cohen and the proposal of the neurotrophic
theory, nerve growth factor (NGF) has become the prototype of a
family of biologically active molecules called neurotrophic factors
(NTFs). This book addresses important advances in NTF research,
from basic science to clinical medicine. It focuses mainly on NGF,
but also includes individual chapters dealing with the
brain-derived neurotrophic factor (BDNF) and ligands of the glial
cell line-derived neurotrophic factor (GDNF) family, which have
attracted increasing interest in the neuroscience community because
of their diverse effects in the normal and diseased brain. In the
first part of the book, the authors provide the necessary
background for the following chapters and discuss the basic
mechanisms and pathways of NGF signal transduction. In the
following sections, they then examine the regenerative activity and
neuroprotective capacity of NGF during development and in normal
and diseased tissues in adulthood and discuss the role of NGF in
Alzheimer's disease and nociception. In addition, the role of NGF
in processing sensory information and its influence on behavior is
further discussed. The book concludes with an overview of the
diagnostic and therapeutic potential of NTF in psychiatric
disorders and obesity management, as well as a highlight of NGF
research in veterinary medicine. Many of the authors of this volume
participated in the Second International Rita Levi-Montalcini
Meeting, held in Bologna, Italy, in 2019. The book covers a wide
range of important topics in past and current NTF research and will
appeal to basic researchers and clinicians alike.
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