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Books > Science & Mathematics > Biology, life sciences > Developmental biology
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Metamorphosis - A Problem in Developmental Biology (Paperback, Softcover reprint of the original 1st ed. 1981)
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Metamorphosis - A Problem in Developmental Biology (Paperback, Softcover reprint of the original 1st ed. 1981)
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"The old order changeth, yielding place to new. " When Tennyson
wrote this, he was unfamiliar with the pace of modem science else
he would have said the new is displaced by the newer. When Gilbert
and I gathered the papers for the first edition of this overview of
metamorphosis, we aimed to provide a broad basis upon which the
experimental analysis of the developmental changes called
metamorphosis could proceed. We were both aware then that with the
new techniques of biochemistry and with the revolutionary
breakthrough to the nature of the gene, countless new possibilities
were being opened for the exploration of the molecular basis of
development. The resources offered by metamorphic changes offered
unique opportunities to trace the path from gene to phenotype. Our
expectations were high. I visited Larry Gilbert and Earl Frieden in
their laboratories and saw with envy how far advanced they were
then in the use of molecular methods of analysis. I had started on
a different approach to develop an in vitro test for thyroid action
on amphibian tissue. But circumstances limited my own progress to
the initial delim itation of the technical possibilities of the in
vitro system. Only from the sidelines could I watch the steady if
slow progress of biology in penetrating the maze of molecular
events by which animal tissues re spond to hormonal and other
developmental factors."
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