A compendium of proven experimental approaches and strategies for
studying the bioactivation, detoxification, tissue distribution,
and elimination of xenobiotics in the metabolism and/or transport
of various chemicals. The authors address several of the major drug
metabolizing systems, including the cytochrome P450 family,
flavin-containing monooxygenases, glutathione, S-transferase,
glucuronidation, N-acetylation, and sulfotransferases. Additional
chapters present novel approaches to the study of: signaling
pathways in the regulation of drug metabolism enzymes, how the
modulation of thiols and other low molecular-weight cofactors can
alter drug metabolism, and how modulation of drug metabolism
pathways can influence antiviral therapy.
General
| Imprint: |
HumanaPress
|
| Country of origin: |
United States |
| Series: |
Methods in Pharmacology and Toxicology |
| Release date: |
October 2010 |
| First published: |
2005 |
| Editors: |
Lawrence H. Lash
|
| Dimensions: |
229 x 152 x 22mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
388 |
| Edition: |
Softcover reprint of hardcover 1st ed. 2005 |
| ISBN-13: |
978-1-61737-494-4 |
| Categories: |
Books >
Medicine >
Nursing & ancillary services >
Pharmacy / dispensing
Promotions
|
| LSN: |
1-61737-494-6 |
| Barcode: |
9781617374944 |
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