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Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
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Thrombin - Structure and Function (Paperback, Softcover reprint of the original 1st ed. 1992)
Loot Price: R1,603
Discovery Miles 16 030
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Thrombin - Structure and Function (Paperback, Softcover reprint of the original 1st ed. 1992)
Expected to ship within 10 - 15 working days
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Research on thrombin structure and function has progressed
significantly over the past three decades. We are continually
discovering new functions f()r this enzyme in biology. Yet, until
quite recently, a full, detailed, three dimensional picture of its
structure was difficult to attain. We believe that this text
represents a turning point and, more appropriately, a new start ing
point for thrombin studies. Our goal for this text is to present a
thorough and rounded-out coverage of thrombin chemistry and biochem
istry in order to provide the biochemist and physiologist with an
excellent desk reference on almost any thrombin-related problem.
This volume is organized into three general thrombin topic areas:
Structure, Biochemistry, and Physiology. In Part 1, Structure, we
open with the complete three-dimensional x-ray structures of two
inhibited human thrombin complexes, one of which is the
thrombin-hirudin com plex. These complexes are also addressed in
the chapter on structural studies in solution, which include NMR,
ESR, and fluorescence. Part 2, Biochemistry, includes chapters on
synthetic thrombin inhibitors, protein inhibitors (e.g.,
antithrombin III, hirudin), and thrombin interactions with factor
XIII. Part 3, Physiology, covers such topics as chemotactic
activities, interactions with cell surfaces, and the vascular
endothelium.
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