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Molecular Orbital Studies in Chemical Pharmacology (Paperback)
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Molecular Orbital Studies in Chemical Pharmacology (Paperback)
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A symposium on molecular orbital studies in chemical pharmacology
was held at the Battelle Seattle Research Center of Batteile
Memorial Institute in Seattle, Washington, U.S.A, on October 20-22,
1969. This volume is a col lection of the lectures presented at
that symposium. The use of quantum mechanics to study the actions
of molecules of biological importance is being developed by a
number of scientists concerned with these phenomena. The advent of
high speed computers has made possible the appl i cation of this
technique to large molecules, of the kind important in living
systems. One result of this expanded computational abi I ity has
been the uti I i zation of molecular orbital theory by a group of
scientists of diverse backgrounds. The lecturers at this symposium,
all interested in molecular orbital theory, have backgrounds in
pharmacology, physical chemistry, theoretical chemistry, bio
chemistry and medicinal chemistry. The common denominator among
these scientists has been the realization that they must search at
the primary level of chemical events for explanations of biological
phenomena. Since these events are governed to a large extent by the
properties of the valence electrons of molecules, molecular orbital
theory offers great promise in explaining and predicting biological
phenomena. October, 1969 Lemont B. Kier Table of Contents v Preface
BERNARD PULLMAN - Electrons in Nucleic Acids and their Cons- tu ent
s JAMES R. HOYLAND - Semiempirical MO Theories: A Critique and 31 a
Rev i ew of Progress ***** . ***.
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