Advances in biotechnology have provided scientists with an
increasing number of biopharmaceuticals such as novel peptide and
protein drugs as well as nucleic acid based drugs for gene therapy.
However, successful delivery of these biopharmaceuticals is a major
challenge because their molecular properties lead to poor physical
and chemical stability in the body and limited membrane
permeability. Therefore researchers are developing a range of new
delivery technologies and materials to enable these new drugs to be
delivered intact to their target sites.
"Delivery Technologies for Biopharmaceuticals" describes
strategies to overcome the main barriers for successful delivery of
therapeutic peptides, proteins, and nucleic acid-based drugs or
vaccines related to the site of administration and the target site.
Many of the approaches described are reported in formulations in
current clinical trials as well as in marketed products. Contents
include:
challenges in delivery of biopharmaceuticalsnovel formulation
approaches for peptide and protein injectablesnon-viral chemical
vectors and viral technology for delivery of nucleic acid based
drugsimmune response, adjuvants and delivery systems for
vaccinesseveral examples of delivery systems for different
biopharmaceuticalsa critical assessment of delivery technologies
for biopharmaceuticals
"Delivery Technologies for Biopharmaceuticals" is an essential
single-volume introduction to the technologies used by researchers
to ensure efficient delivery of this exciting new class of drugs.
It will be of value to researchers and students working in drug
delivery, formulation, biopharmaceuticals, medicinal chemistry, and
new materials development.
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