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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Immunology and Infectious Disease (Hardcover, 2003 ed.)
Loot Price: R3,044
Discovery Miles 30 440
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Immunology and Infectious Disease (Hardcover, 2003 ed.)
Series: Molecular & Cellular Biology of Critical Care Medicine, 3
Expected to ship within 10 - 15 working days
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Individualized dosing regimens specific to the patient, infection,
bacteria, and antibiotic can optimize outcome. Integration of
pharmacokinetic and pharmacodynamic data, called dual
individualization, can be accomplished through the use of AUIe.
AUIC dosing has been shown to predict bacteriological outcomes,
hasten clinical outcomes, reduce the emergence of resistance, and
be cost-effective. MPC dosing has been shown to predict the
emergence of resistant submutants. AUIC and MPC information can
provide guidance as to when low doses can be used, and when higher
concentrations are required. This strategy can ensure efficacy,
minimize toxicity, reduce the opportunity for resistance to occur,
and save money. REFERENCES I. Paladino JA. Streamlining antibiotic
therapy: clinical application of pharmacokinetic and
pharmacodynamic principles. J Osteopath Med 1991; 5: 16-25. 2. Liss
RH, Batchelor FR. Economic evaluations of antibiotic use and
resistance - a perspective: report of task force 6. Rev Infect Dis
1987; 9 (suppI3): S297-312. 3. Holmberg SO, Solomon SL, Blake PA.
Health and economic impacts of antimicrobial resistance. Rev Infect
Dis 1987; 9: 1065-78. 4. Sanders cc. Mechanisms responsible for
cross-resistance and dichotomous resistance among the quinolones.
Clin Infect Dis 2001; 32(Suppl I ): S 1-8. 5. Ballow CH, Schentag
11. Trends in antibiotic utilization and bacterial resistance:
report of the NNRSG. Diagn Microbiol Infect Dis. 1992;
15(suppl):37S-42S. 6. Rice LB, Eckstein EC, DeVente J, Shlaes OM.
Ceftazidime-resistant Klebsiella pneumoniae isolates recovered at
the Cleveland Department of Veterans Affairs Medical Center. Clin
Infect Dis 1996; 23: 118-24
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