Neuroscience's inherent complexity and rapid growth mean that no
one can keep abreast of all the changes across the field. We each
bring a necessarily narrow perspective. Neurotherapeutics: Emerg
ing Strategies is an attempt to provide some diverse perspectives
within the hunt for new drugs to treat central nervous system
diseases. The book's premise is that the search for new drugs is
based on an understanding ofboth clinical and basic sciences.
Neurotherapeu tics: Emerging Strategies begins with psychiatry and
concludes with neurological disorders. Each chapter examines a
disease, including clinical features and existing treatments, but
the emphasis is on current concepts of underlying causes and novel
strategies for drug discovery arising from these possible
mechanisms. Participating authors include basic neuroscientists,
industry-based pharmacolo gists and chemists, and clinicians. The
chapters describe the status of the existing disease treat ments,
and when treatments are lacking, the approach is more basic science
oriented. When there is a long history of treatment, there is
greater emphasis on those therapies. However, all the chapters seem
to reflect the benefits of cloning, since the availability of
receptor subtypes now promises the opportunity for greater
specificity of drug effects. Modulation of second messengers is
another new and recur ring theme. And in the chapter on cachexia,
cytokines are explored both as drugs and drug targets.
Neurotherapeutics: Emerging Strategies reflects the complex ity of
the nervous system, but the overriding message is hope for new and
better drugs to treat those diseases that rob us of ourselves."
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