One hundred years have elapsed since specific allergen
immunotherapy (SIT) was first employed and found to be effective in
the treatment of allergic respiratory diseases. This cutting-edge
issue of Immunology and Allergy Clinics offers a comprehensive
review of this disease modifying treatment, exploring its history,
status, and potential future. Topics covered include the mechanisms
of subcutaneous allergen immunotherapy; the mechanisms of
sublingual immunotherapy; optimizing efficacy of subcutaneous
immunotherapy; preparation of allergen immunotherapy extraxcts;
risk factors and subcutaneous immunotherapy safety; accelerated
schedules and reducing risk with premedication (antihistamines,
omalizumab, leucotriene antagonist); safety and efficacy of
sublingual immunotherapy for allergic respiratory disease and other
indications; monitoring clinical outcomes of specific
immunotherapy; monitoring immunotherapy response with immunological
parameters; socioeconomics and comparative effectiveness of
immunotherapy; oral desensitization for food hypersensitivity;
peptide and recombinant immunotherapy; intralymphatic and
epicutaneous allergen-specific immunotherapy; peptide and
recombinant immunotherapy; adjuvants and vector systems for allergy
faccines; and future forms of immunotherapy.
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