A coordinated approach using biochemical and immunological tools
has given us a better understanding of the structure of the
eukaryotic surface membrane. From such studies has emerged the
fluid mosaic model of membrane structure and this volume contains a
collection of articles written by noted workers in this field. A
major emphasis in this area of research concerns the changes
brought about on virus-induced and carcinogen-induced tumor cells.
The first chapter comes from a laboratory that was one of the first
to visualize the distribution of transplantation antigens on cell
membrane surfaces. Various methods are described for visualizing
these antigens by electron microscopy. Davis and his colleagues
then proceed to show how the antibody-induced redistribution of
antigenic macromolecules led to the formulation of the fluid mosaic
model. From Hakomori's labora tory comes a methodological paper
describing a novel method of labeling the carbohydrate portions of
the membrane glycoproteins that are exposed on the outer surfaces
of cells. The two chapters reviewing the changes found on
carcinogen-induced and virus-induced malignant cells complete the
survey of the structures associated with surface mem branes. Thanks
are due to Mrs. Carol Garafolo who helped immeasurably with the
preparation of the index for this volume."
General
Imprint: |
Springer-Verlag New York
|
Country of origin: |
United States |
Series: |
Biomembranes, 8 |
Release date: |
April 2013 |
First published: |
1976 |
Authors: |
Lionel A. Manson
|
Dimensions: |
229 x 152 x 13mm (L x W x T) |
Format: |
Paperback
|
Pages: |
244 |
Edition: |
Softcover reprint of the original 1st ed. 1976 |
ISBN-13: |
978-1-4684-9089-3 |
Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
Biochemistry >
General
|
LSN: |
1-4684-9089-3 |
Barcode: |
9781468490893 |
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