Signal Transduction and the Coordination of B Lymphocyte Development and Function I - Transduction of BCR Signals from the Cell Membrane to the Nucleus (Hardcover, 2000 ed.)

Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical."

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Current Topics in Microbiology and Immunology, 245/1
Release date:	2001
First published:	2000
Editors:	Louis B. Justement • Katherine A. Siminovitch
Dimensions:	235 x 155 x 17mm (L x W x T)
Format:	Hardcover
Pages:	267
Edition:	2000 ed.
ISBN-13:	978-3-540-66002-6
Categories:	Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General Promotions
LSN:	3-540-66002-X
Barcode:	9783540660026

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