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BNIP3 in Cyanide-induced Brain Damage (Paperback)
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BNIP3 in Cyanide-induced Brain Damage (Paperback)
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In this study, an immortalized dopaminergic cell line was used to
characterize the cell death signaling cascade activated by cyanide.
Cyanide activated the HIF-1 -mediated pathway of BNIP3 induction
through a redox-sensitive process. Increased BNIP3 expression then
served as an initiator of mitochondria-mediated death. In mice,
repeated exposure to a sublethal dose of cyanide resulted in an
increase of BNIP3 expression in midbrain, which was accompanied by
a loss of dopaminergic neurons. In cortex, cyanide induced
upregulation of BNIP3, which may be involved in cortical cell
apoptosis. It is also shown that BNIP3 was localized in both ER and
mitochondria to facilitate the release of Ca2+ from ER and
subsequently increase uptake of Ca2+ into mitochondria. Excessive
accumulation of mitochondrial Ca2+ facilitated the loss of m,
ultimately resulting in the execution of cell death. Current
results also confirm that Bax was activated and co-localized with
BNIP3 in ER and mitochondria. Acting as a downstream effector for
BNIP3, Bax is required for Ca2+ crosstalk between ER and
mitochondria, thereby contributing to mitochondria-mediated cell
apoptosis."
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
July 2010 |
First published: |
July 2010 |
Authors: |
Lu Zhang
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Dimensions: |
229 x 152 x 11mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
188 |
ISBN-13: |
978-3-8383-5714-0 |
Categories: |
Books >
Medicine >
Other branches of medicine >
Pharmacology >
General
|
LSN: |
3-8383-5714-0 |
Barcode: |
9783838357140 |
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