This key volume of the Target Organ Toxicology Series provides a
fresh and modern approach to the subject of skin toxicology from
the perspective of how the skin forms a barrier that protects the
body from the external environment and how chemicals and drugs
interact with the barrier properties of the skin. Any defects or
perturbations to this barrier may result in damage to the skin or
may alter absorption. With contributions from over 40 international
experts in the field of skin biology, the book presents the central
role of the skin barrier to health and disease reviewing; The
skin's anatomy and physiology, with focus on the stratum corneum as
a barrier to foreign substances. Dermal absorption, cutaneous
metabolism, and epidermal transporters. Altered barriers, racial
skin types, aged skin, photoaged skin, cosmetics and skin
sensitization. Modern approaches to drug delivery across the skin
barrier, including liposomes, microneedle technology, active and
passive transdermal delivery. Examples and case studies of chemical
toxicity after topical exposures ranging from arsenic, metal
working fluids, bromine, jet fuel, sulfur mustard and including the
emerging area of nanomaterial penetration. Toxicology of the Skin
is essential reading for drug delivery pharmacologist, formulation
scientists, dermatologists, toxicologists, molecular biologists,
engineers, surgeons, students and anyone interested in skin
irritation and skin absorption.
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