The detection of neurotransmitter receptor locations and
distribution densities within the central nervous system and
peripheral tissues is receiving intense attention within the
neuroscience research community. Neurotransmitter receptors, which
receive the chemical signals sent from one neuron to another, are
critical links in a highly complex information-processing chain.
Pinpointing receptor sites and systems is crucial for understanding
neurological function as well as dysfunction. It is also essential
for understanding how receptors process information when impacted
by such substances as heroin or nicotine, or when affected by
neurodegenerative disease.
Receptor Localization: Laboratory Methods and Procedures is the
first user-friendly guide to the latest techniques and approaches
being employed to examine the localization of neurotransmitter
receptors in the central nervous system and peripheral tissues. It
covers detection methods that are applicable to a wide variety of
receptor systems, ranging from genes and ligands to in vito
receptors in individuals; and to numerous receptor subtypes, such
as nicotine, muscarine, tackykinins, dopamine, adenosine, and GABA.
The standard laboratory "recipes" or "tricks" employed in these
detection methods are fully discussed, as are the advantages and
limitations of each procedure. With contributions from leading
experts and extensively illustrated, this book:
* Discusses receptor ligand binding methods using irreversible and
reversible compounds
* Presents antireceptor antisera technology using synthetic
peptides and fusion proteins at both the cellular and subcellular
resolution levels
* Examines molecular assessments of receptors
* Describes in situ hybridization, reverse transcriptase-PCR, and
fluorescent in situ transcription
* Covers new visualization paradigms
* Includes physiological analysis of receptor function, cellular
detection in the brain slice, and cultured neurons
* Discusses the use of PET and SPECT to assess in vivo receptor
distributions in animals and humans
Receptor Localization: Laboratory Methods and Procedures is an
invaluable guide for researchers in the related fields of
neurology, biochemistry, and pharmacology. Its lucid descriptions
of new detection methods, inclusion of experimental examples, and
emphasis on how these experimental approaches are applicable to
particular research areas will appeal to both the experienced
researcher and novice investigator.
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