Ever since the emergence of the concept of catharral jaundice by
Virchow, viral hepatitis has eluded scientists as a pathogenetic
enigma. A tremendous new impetus was given to hepatitis research by
Baruch Blumberg's discovery of his 'Australia Antigen', now known
as hepatitis B surface antigen. This led to an unheard-of outburst
of research activity to elucidate the nature of the virus, its
chemical and antigenic composition, its epidemiology, and
pathogenetic mechanisms in the causation of liver disease.
Coinciding with this period, modern medical science witnessed
impressive progress in the analysis of the extraordinarily complex
mechanism of immunological reactions. Immunohistochemical
techniques for the detection of hepatitis B viral components are a
product of this scientific progress in both areas. The application
of such tech niques forms the core of this work. It represents a
vast amount of work, performed during the course of several years,
with meticulous application of advanced immunohisto chemical
techniques, combined with histopathology and clinical-patho logical
methods. This has resulted in the compilation of original results
and new insights into the cellular and tissular localization of the
anti genic components of the hepatitis B virus in different forms
of chronic liver disease. The most outstanding results are the
demonstration of the superior sensitivity of the applied
immunohistochemical technique in the search for viral components in
chronic hepatitis patients. and the differ ential distribution
patterns of hepatitis B surface antigen in the various forms of
chronic liver disease."
General
| Imprint: |
Springer
|
| Country of origin: |
Netherlands |
| Release date: |
February 2012 |
| First published: |
1979 |
| Authors: |
M. Bray
|
| Dimensions: |
235 x 155 x 10mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
165 |
| Edition: |
Softcover reprint of the original 1st ed. 1979 |
| ISBN-13: |
978-9401162371 |
| Categories: |
Books >
Medicine >
Clinical & internal medicine >
Hepatology
|
| LSN: |
9401162379 |
| Barcode: |
9789401162371 |
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