These volumes present the results of two studies undertaken for the
Directorate General of Employment, Social Affairs and Education of
the Commission of the European Communities. The aim was to review
available data concerning the metabolism of a selection of toxic
chemi cals in man and to develop mathematical models representing
this meta bolism. Volume 1 is the report from the first study and
presents re views of the data for each of the substances and
proposes models for their metabolic behaviour. Volume 2 is the
report of the second study and contains a review of new data
relevant to the development of meta bolic models for each
substance. The modelling of uptake and retention by the two major
routes of uptake (the respiratory system and the gas trointestinal
tract) is also reviewed. The implementation of the models in a
computer code is described and results are presented illus trating
organ concentrations and rates of excretion for typical regimes of
exposure. vi 1 Foreword This report contains the results of a study
undertaken by Associated Nuclear Services (ANS) for the Directorate
General of Employment, Social Affairs and Education of the
Commission of the European Communities (CEC). This study was
entitled "Models for the Metabolism of Chemical Carcinogens in
Man." vii 2 Summary This report includes results of a review of the
metabolism of selected actual and potential human carcinogens and
proposals for pharmacokinetic models to represent that metabolism."
General
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