Many elderly patients find difficulty to swallow tablets or
capsules. It is estimated that 50% of the population is affected by
this problem which results in a high incidence of incompliance and
ineffective therapy for this reason the development of oral
dispersible tablets (ODT) or rapidly disintegrating tablets (RDT)
have recently interested not only the pharmaceutical industry, but
also academia. In order to solve this problem, the development of
solid dosage form that disintegrates rapidly or dissolves even when
taken orally without the aid of water are being formulated. These
dosage forms are known as oral dispersible tablets.The solid ODT
dosage form turns into a soft paste or liquid form for easy
swallowing, and thus it is free of suffocation risk. Dispersible
tablet undergo disaggregation in the mouth when in contact with the
saliva in less than 60 seconds, preferably in less than 40 seconds,
forming a suspension which is easy to swallow. The drug Cinnarzine
was selected because it is antihistaminic category drug and used in
the treatment of motion sickness for that fast action is required
and that can be fulfilled by ODT
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