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Parkinson's Disease - Methods and Protocols (Hardcover, 2001 ed.)
Loot Price: R2,842
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Parkinson's Disease - Methods and Protocols (Hardcover, 2001 ed.)
Series: Methods in Molecular Medicine, 62
Expected to ship within 10 - 15 working days
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Parkinson's disease is a progressive neurodegenerative disorder
charact- ized clinically by tremor, rigidity, slow movements, and
postural instability. Pathologically, dopaminergic neurons of the
substantia nigra bear the brunt of the degeneration, though other
neuronal groups can be affected as well. Although Parkinson's
disease is the only neurodegenerative disorder for which effective
therapies are available, these treatment options are only
symptomatic, do not influence the underlying degenerative process,
and are associated with a high incidence of complications,
particularly with their long-term use. The progressive nature of
the disease and the limitations of its palliative therapies result
in significant functional impairment. The chronic disability and
the increased prevalence of the disease with the prolongation of
life expectancy in developed countries make the social and economic
impact of this disease quite high. For- nately, systematic basic
and clinical research in this disease has yielded major new
advances that render patients' hopes for a cure considerably closer
to reality. The application of molecular biologic methodologies in
the study of Parkinson's disease has begun to have a major impact
only in recent years. Con- quently, the utility of these
technologies is largely in the research arena, although their
clinical applications are now being realized.
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