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Books > Medicine > Clinical & internal medicine > Hepatology
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Immunology and Liver (Hardcover, 2000 ed.)
Loot Price: R4,589
Discovery Miles 45 890
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Immunology and Liver (Hardcover, 2000 ed.)
Series: Falk Symposium, 114
Expected to ship within 10 - 15 working days
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In 1992, the Falk Symposium No. 70 dealt with the topic Immunology
and Liver'. At that time basic mechanisms of immunology as well as
immunopathogenetic mechanisms in viral and autoimmune liver
diseases were discussed. Now, 7 years later, the Falk Symposium No.
114, held in Basel, Switzerland, October 20-21 1999 (Part I of the
Basel Liver Week 1999), focused on immunology in autoimmune liver
diseases. In the first section basic mechanisms of autoimmunity are
presented, including the relevance of superantigens and the role of
apoptosis. A further topic is the latest developments concerning
animal models for autoimmune diseases. Recently the International
Autoimmune Hepatitis Group newly defined and reclassified the
syndrome of autoimmune hepatitis. Autoimmune hepatitis is now
identified and studied in all parts of the world, including Asia
and South America. A special variant of autoimmune hepatitis was
identified as one organ manifestation of the autoimmune
polyendocrine syndrome type 1, a genetic disease caused by
mutations in a single transcription factor. Drug- and
hepatitis-virus induced immune mediated liver diseases may serve as
models for nonhepatic immune mediated disorders. DNA technology has
increased our knowledge of the immunogenetic background of
autoimmune liver diseases. Among the cholestatic immune mediated
liver diseases, significant progress has been made concerning
primary biliary cirrhosis, in particular regarding the
identification of mitochondrial antigens and the characterisation
of the immune reactions directed at them. The involvement of
infectious agents in PBC as well as the definition of overlap
syndromes is a particular focus for basic and clinical research in
this area. Concerning the therapy of autoimmune liver diseases,
corticosteroids and azathioprin remain the state of the art for
autoimmune hepatitis, while bile acids have become well established
in treatment of primary biliary cirrhosis as well as primary
sclerosing cholangitis. New drugs in the future will include
topical steroids such as budesonide and new immunosuppressive
agents like mofetil/mycophenolate. Liver transplantation is the
treatment of choice for end stage liver diseases; all autoimmune
liver diseases are among the best candidates for liver
transplantation. Hopefully, new therapeutic strategies based on the
results obtained from experimental models will become everyday
clinical practice in the next decade. Therefore this symposium
concludes with a discussion.
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