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Books > Medicine > General issues > Medical ethics
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Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery (Hardcover)
Loot Price: R2,919
Discovery Miles 29 190
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Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery (Hardcover)
Series: IOP Concise Physics
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The concept of smart drug delivery vehicles involves designing and
preparing a nanostructure (or microstructure) that can be loaded
with a cargo. This can be a therapeutic drug, a contrast agent for
imaging, or a nucleic acid for gene therapy. The nanocarrier serves
to protect the cargo from degradation by enzymes in the body, to
enhance the solubility of insoluble drugs, to extend the
circulation half-life, and to enhance its penetration and
accumulation at the target site. Importantly, smart nanocarriers
can be designed to be responsive to a specific stimulus, so that
the cargo is only released or activated when desired. In this
volume we cover smart nanocarriers that respond to internal stimuli
that are intrinsic to the target site. These stimuli are specific
to the cell type, tissue or organ type, or to the disease state
(cancer, infection, inflammation etc). pH-responsive nanostructures
can be used for cargo release in acidic endosomal compartments, in
the lower pH of tumors, and for specific oral delivery either to
the stomach or intestine. Nanocarriers can be designed to be
substrates of a wide-range of enzymes that are over-expressed at
disease sites. Oxidation and reduction reactions can be taken
advantage of in smart nanocarriers by judicious molecular design.
Likewise, nanocarriers can be designed to respond to a range of
specific biomolecules that may occur at the target site. In this
volume we also cover dual and multi-responsive systems that combine
stimuli that could be either internal or external.
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