Chemical synthesis is one of the key technologies underlying
modern drug discovery and development. For the design and
accessibility of novel structures and the rapid preparation of new
test compounds and development candidates with often highly complex
chemical architecture, it is essential to use state-of-the-art
chemical synthesis technologies. Recent developments in the field
of asymmetric catalysis point to a third class of catalysts besides
the established enzymes and metal complexes, so-called
organocatalysts. These low-molecular-weight, organic molecules
enable highly chemo- and stereoselective chemical transformations
for the rapid assembly of complex bioactive molecules of interest
for the pharmaceutical industry.
This book presents the contributions from leading experts, with
backgrounds in academia and industry, to an Ernst Schering Research
Foundation Symposium held in April 2007. It illustrates current
progress in organocatalysis in functional group interconversions,
organocatalytic CC- and CX-bond formations with small molecules as
well as peptide-based catalysts and genetically engineered enzymes
and their applications in natural product and drug syntheses. It
will be of interest to those who want a general overview of the
topic, but also to those who want to learn more about the state of
the art, current trends and perspectives in this highly dynamic
field of research.
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