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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Cytokine Protocols (Hardcover, 2004 ed.)
Loot Price: R3,020
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Cytokine Protocols (Hardcover, 2004 ed.)
Series: Methods in Molecular Biology, 249
Expected to ship within 10 - 15 working days
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During the last 30 years there has been a growing interest in
cytokines as biological molecules able to regulate the most diverse
functions in living org- isms, mainly at the level of cell-cell
communication. Originally their definition was limited to the cells
of the immune system (interleukins and lymphokines), but later that
definition was extended to all cells, and their regulatory activity
in such other processes as differentiation, apoptosis,
angiogenesis, and wound he- ing has been now demonstrated. They
comprise a group of small proteins (5-20 kDa) produced and released
by cells in a tightly controlled fashion, active in the nano- or
picomolar concentration range, and eliciting specific effects in
nei- boring cells; therefore, their action is said to be autocrine,
paracrine, or jux- crine. The latter property distinguishes them
from hormones, which are produced by one tissue and are transported
by the blood stream in order to act on a distant tissue. Chemokines
are a subset of cytokines, but whether growth factors are included
in the group is often a matter of discussion. The activity of
several cytokines can be inhibited by other cytokines or by
biological response modi- ers; therefore, the latter are sometimes
called "anti-cytokines. " The biological response of a particular
cell is usually the result of the sum of all interactions with
cytokines present at a certain time and in a certain sequence in
time-the "cytokine network.
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