Members of the Rho family of small GTP-binding proteins (GTPases)
are key signal transduction proteins that mediate signals initiated
by growth factors, cytokines and cell adhesion proteins. Our
knowledge about Rho GTPases has rapidly expanded over the past
several years and Rho GTPases is the first book to provide a
comprehensive overview of the regulation and functions of this
important class of proteins.
This book includes several chapters dedicated to the review of
various classes of proteins that control the localization and
activation state of Rho GTPases. Additional chapters discuss the
wide range of biological functions that are controlled by Rho
GTPases, including the organization of the actin cytoskeleton, cell
proliferation and cell motility.
Rho GTPases is essential reading for cell and molecular biologists,
biochemists and geneticists. The critical roles of Rho family
members in cancer and inflammatory diseases makes Rho GTPases also
an invaluable guide for clinical investigators and pharmacologists.
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