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Staphylococcus aureus - Infections, Treatment & Risk Assessment (Paperback)
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Staphylococcus aureus - Infections, Treatment & Risk Assessment (Paperback)
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This book provides an overview of the different topics of
staphylococcal research in recent years. Severe infections caused
by methicillin-resistant Staphylococcus aureus (MRSA) have become a
global health problem in the twenty-first century. Chapter One
discusses MRSA as a major cause of healthcare or
hospital-associated infections (HA-MRSA) in burn patients,
indicated as a high-risk group for invasive staphylococcal
infection. Types of MRSA, which have traditionally been tackled as
exclusive agents of healthcare-associated infections, are now
recognized as the causative agents of severe disease acquired in
the community. The second chapter discusses these infections as
they occur mainly in special populations. For example, we may cite
people living with HIV/AIDS, older adults living in long-term care
facilities and patients with chronic diseases, notably diabetes
mellitus. In Chapter Three, a third epidemiological form of MRSA is
discussed, which is known as livestock-associated MRSA (LA-MRSA).
Chapter Four emphasizes the current scenario of highly adaptable
clonal complexes. Among these strains, LA-MRSA belonging to clonal
complex (CC) 398 are particularly important, and nosocomial
infections caused by strains of CC398 are frequently reported.
Confirmation of the presence of microorganisms in blood cultures is
one of the most important roles of clinical microbiology
laboratories. Blood culture testing - the gold standard for the
diagnosis of sepsis - is able to elucidate the etiology of
infection and to establish appropriate antibiotic treatment in
order to improve the prognosis of septic patients and,
consequently, to reduce morbidity and mortality; this is the
subject discussed in Chapter Five. Nosocomial infections manifest
more intensely and more frequently in newborns when compared to
children or adults. Staphylococcus aureus infections in newborns is
discussed in Chapter Six. Staphylococcus spp. are an important
cause of peritonitis in peritoneal dialysis (PD), frequently
requiring change of the dialysis technique and causing an important
impact on the mortality of PD patients, another matter of great
importance which is discussed in Chapter Seven. Finally, the
epidemiology and experimental evidence that S. aureus and its
products, the superantigens, are directly related to the
development or exacerbation of autoimmune diseases, which are
discussed in Chapter Eight. This book provides an excellent
overview of the different applications of staphylococcal research
for clinicians, researchers and students who intend to address
these issues, and permits continued high-quality research involving
these important pathogens.
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