Sex and Gender Differences in Alzheimer's Disease: The Women's
Brain Project offers for the first time a critical overview of the
evidence documenting sex and gender differences in Alzheimer's
disease neurobiology, biomarkers, clinical presentation, treatment,
clinical trials and their outcomes, and socioeconomic impact on
both patients and caregivers. This knowledge is crucial for
clinical development, digital health solutions, as well as social
and psychological support to Alzheimer's disease families, in the
frame of a precision medicine approach to Alzheimer's disease. This
book brings together up-to-date findings from a variety of experts,
covering basic neuroscience, epidemiology, diagnosis, treatment,
clinical trials development, socioeconomic factors, and
psychosocial support. Alzheimer's disease, the most common form of
dementia, remains an unmet medical need for the planet. Wide
interpersonal variability in disease onset, presentation, and
biomarker profile make Alzheimer's a clinical challenge to
neuroscientists, clinicians, and drug developers alike, resulting
in huge management costs for health systems and society. Not only
do women represent the majority of Alzheimer's disease patients,
but they also represent two-thirds of caregivers. Understanding sex
and gender differences in Alzheimer's disease will lead to novel
insights into disease mechanisms, and will be crucial for
personalized disease management strategies and solutions, involving
both the patient and their family. Endorsements/Reviews: "There is
a clear sex and gender gap in outcomes for brain health disorders
like Alzheimer's disease, with strikingly negative outcomes for
women. This understanding calls for a more systematic way of
approaching this issue of inequality. This book effectively
highlights and frames inequalities in all areas across the
translational spectrum from bench-to-bedside and from
boardroom-to-policy and economics. Closing the Brain Health Gap
will help economies create recovery and prepare our systems for
future global shocks." Harris A. Eyre MBBS, PhD, co-lead,
Neuroscience-inspired Policy Initiative, OECD and PRODEO Institute.
Instructor in Brain Health Diplomacy, Global Brain Health
Institute, UCSF and TCD. "Sex and Gender Differences in Alzheimer's
disease is the most important title to emerge on Alzheimer's
disease in recent years.This comprehensive, multidisciplinary book
is a must read for anyone with a serious interest in dementia
prevention, diagnosis, treatment, care, cure and research.
Precision medicine is the future of healthcare and this book
represents an incredible and necessary resource to guide practice,
policy and research in light of the fact that Alzheimer's disease
disproportionately affects women. The combination of contributions
from the most eminent experts and the most up-to-date research
makes this an invaluable resource for clinicians, care providers,
academics, researchers and policy makers. Given the complex nature
of dementia and the multiple factors that influence risk and
disease trajectory the scope of the book is both impressive and
important covering sex differences in neurobiological processes,
sex and gender differences in clinical aspects and gender
differences linked to socioeconomic factors relevant to Alzheimer's
disease. If you work in Alzheimer's disease, or indeed other
dementias, then Sex and Gender Differences in Alzheimer's disease
is a must have for your bookshelf." -- Sabina Brennan, PhD.,
C.Psychol.,PsSI., National representative for Ireland on Alzheimer
Disease International's Medical and Scientific Advisory Panel
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