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XIth International Symposium on Amyloidosis (Hardcover)
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XIth International Symposium on Amyloidosis (Hardcover)
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Edited by a stellar team of scientists compiling more than 120
papers into a single volume, the XIth Annual International
Symposium on Amyloidosis represents the most important review of
the state-of-the-science and future directions of this rapidly
growing field. An unparalleled cast of pioneering researchers,
including keynote speaker and Nobel Laureate Dr. Stanley Prusiner,
present groundbreaking research in systemic amyloidosis including
the mechanisms of disease and cellular toxicity, AA amyloidosis,
familial amyloidosis, AL amyloidosis, clinical trials, and emerging
Divided into six sections, the book begins with a study of the
mechanisms of fibril formation and cellular response. It
investigates possible horizontal transmission, charge differences
of deposits in AL and NALCDD, and novel assays to detect amyloid
induced apoptosis. The second section considers AA and localized
amyloidosis and presents advances in non-invasive imaging, amyloid
typing, and the translocation of systemic amyloidosis. The section
on familial and TTR amyloidosis features an original report on
hereditary gelsolin amyloidosis in an Iranian family, as well as
other novel and rare mutations. An extensive section on AL
amyloidosis introduces ALBASE as a platform analysis tool, AL
amyloidosis in the elderly, and a study of the therapeutic
potential of naturally occurring antibodies. Section five focuses
on new and emerging diagnostic and translational approaches
including characterization and identification through biopsy, mass
spectrometry, proteomics, and the use of an amyloid "chip". The
book concludes with clinical trials of diflunisal and high dose
melphalan-dexamethasone and autologous stem cell transplantation.
translational approaches. Focusing on new basic and translational
medicine approaches in systemic amyloidosis, XIth Annual
International Symposium on Amyloidosis provides clinicians and
researchers with an invaluable single source reference to the most
up-to-date research in the field.
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