A comprehensive understanding of the biology of prion diseases is
crucial for risk assessment as regards both humans and animals. To
further the communication of the current knowledge and the exchange
of diagnostic technologies in the scientific community, a symposium
on the 'Characterization and Diagnosis of Prion Diseases' was held
from September 23-25, 1999 in Tubingen, Germany. The overwhelming
interest and the participation of more than 500 scientists from 26
countries made this symposium the largest meeting ever held in the
field. In this Supplementum to Archives of Virology twenty-six
invited speakers comprehensively present their data on the
pathogenesis of prion diseases in humans and animals, on molecular
mechanisms involved in the transmissibility across species
barriers, on animal and in-vitro models currently available for the
detection and quantification of infectivity and on the
characterization of prion strains. This selection attempts to
reflect the current state of the art, but cannot possibly represent
the whole spectrum of research in the prion field."
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