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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens - A Novel NMR-Tool for Natural Product Detection (Hardcover, 2014 ed.)
Loot Price: R1,440
Discovery Miles 14 400
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NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens - A Novel NMR-Tool for Natural Product Detection (Hardcover, 2014 ed.)
Series: Springer Theses
Expected to ship within 10 - 15 working days
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Martin Stein's thesis describes a novel methodology for natural
product discovery. Due to its high degree of reproducibility,
robustness and sensitivity, the technique can be utilized to detect
even trace amounts of bioactive substances in heterogeneous
matrices such as fermentation broths or crude organic extracts.
This research is thus relevant for a large number of researchers
working in natural product discovery. Applications of this novel
NMR-based approach include suitable environmental triggers for the
induction of biosynthetic machineries. The author demonstrates the
extraordinary value of this approach by the successful isolation of
two potent inhibitors of the pharmaceutically relevant proteasome
core particle from the insect pathogen photorhabdus luminescens.
This thesis has led to a number of publications in high-impact
journals.
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