The calcium metabolism in the living body is skilfully regulated
through calcium-regulating hormones, including the parathyroid
hormone, active vitamin D3 metabolite and calcitonin. The blood
calcium concentration is ten thousand-fold compared with the levels
in cells. Cells use extracellular calcium to regulate cell function
efficiently. Intracellular calcium homeostasis is exactly regulated
through the mechanism related to various calcium transport systems
in cells. Signal transduction plays a pivotal role in cellular
regulation. Calcium signalling is probably the most ubiquitous
cellular signal that mediates the action of many hormones,
cytokines, and neurotransmitters. Calcium regulates the activity of
numerous calcium-dependent proteins including protein kinases,
protein phosphatases, protease and other calcium-regulating factors
involved in calcium signalling. Calcium signalling plays a pivotal
role in the regulation of manifold cellular functions including
cell proliferation, apoptosis and gene expression. This book
focuses on recent topics in calcium signalling and its related
diseases.
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