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Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders (Hardcover, 2014 ed.)
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Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders (Hardcover, 2014 ed.)
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Recent studies show that changes in Glutamate/GABA synapses and
related pathways may determine whether the synaptic plasticity that
occurs as a response to stress is adaptive or maladaptive. Findings
have shed new light on the mechanisms that determine the effects of
stress on cognitive and affective function. Researchers have
brought a wide range of techniques to bear on the study of this
problem, including cutting-edge live imaging techniques,
electrophysiology, glutamate release from isolated live synaptic
terminals, development of transgenic and animal models and new
behavioral methods. This book provides an overview of these recent
findings and of the techniques used as well as a discussion of how
the molecular, cellular, and functional effects of stress may
trigger or precipitate neuropsychiatric disorders such as
depression, schizophrenia, anxiety and PTSD.
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