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Evolutionary Biology - Volume 16 (Paperback, Softcover reprint of the original 1st ed. 1983)
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Evolutionary Biology - Volume 16 (Paperback, Softcover reprint of the original 1st ed. 1983)
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Sixteen volumes and one supplement have now appeared in the series
known as Evolutionary Biology. The editors continue to seek
critical re views, original papers, and commentaries on
controversial topics. It is our aim to publish papers primarily of
greater length and depth than those normally published by society
journals and quarterlies. The editors make every attempt to solicit
manuscripts on an international scale and to see that every facet
of evolutionary biology-classical or modern-is cov ered.
Manuscripts should be sent to anyone of the following: Max K.
Hecht, Department of Biology, Queens College of the City University
of New York, Flushing, New York 11367; Bruce Wallace, Department of
Biology, Virginia Polytechnic Institute and State University,
Blacksburg, Virginia 24061; Ghillean T. Prance, New York Botanical
Garden, Bronx, New York 10458. The Editors vii Contents 1.
Darwinian Selection of Self-Replicating RNA Molecules 1 Christ( r
K. Biehricher Introduction . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . Replication of Virus RNA in
Vitro. . . . . . . . . . . . . . . . . . . . . . . . 2
Extracellular Darwinian Experiments. . . . . . . . . . . . . . . .
. . . . . . 5 Characterization of the QI3 Replicase. . . . . . . .
. . . . . . . . . . . . . . 9 Nonviral RNA Templates of QI3
Replicase. . . . . . . . . . . . . . . . . . II The Mechanism of
RNA Replication . . . . . . . . . . . . . . . . . . . . . . 14
Initiation of Replication and Template Specificity . . . . . . . .
. . . 14 Mechanism of Replica Chain Elongation. . . . . . . . . . .
. . . . . . . 17 Termination of Replication. . . . . . . . . . . .
. . . . . . . . . . . . . . . . 19 Replication of RNA Variants . .
. . . . . . . . . . . . . . . . . . . . . . . . 21 The Quasispecies
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . 23 De NOl'O Synthesis of Self-Replicating RNA. . . . . . . .
. . . . . . . . . 27 The Mechanism of Selection . . . . . . . . . .
. . . . . . . . . . . . . . . . . . 32 Selection in the Exponential
Growth Phase. . . . . . . . . . . . . . . . 32 Selection in the
Linear Growth Phase. . . . . . . . . . . . . . . . . . . . 35
Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 41 Appendix I. Replication. . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . 42 Appendix II. The
Quasispecies. . . . . . . . . . . . . . . . . . . . . . . . . . .
43 Appendix III. Selection under Various Conditions . . . . . . . .
. . . . 44 References . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . ."
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