CACO-2 cell cultures are widely used in vitro models in several
scientific fields such as nutrition, physiopathology, pharmacology,
and toxicology. When cultured onto filters, these cells form a
highly polarised epithelium that allows discrimination between
apical and basolateral compartments. This book presents topical
research in the study of CACO-2 cells and their uses. Topics
discussed include the application of CACO-2 cell models as a
supportive in vitro tool during drug discovery and formulation;
co-culture systems with CACO-2 cells to evaluate the bioactivity of
plant extracts and the use of CACO-2 cells in intestinal transport,
cell-matrix interactions and wound healing in intestinal villus
cells.
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