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Handbook of the Hemopoietic Microenvironment (Hardcover, 1989 ed.)
Loot Price: R3,284
Discovery Miles 32 840
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Handbook of the Hemopoietic Microenvironment (Hardcover, 1989 ed.)
Series: Contemporary Biomedicine, 9
Expected to ship within 12 - 17 working days
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Total price: R3,304
Discovery Miles: 33 040
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In 1868, Ernst Neumann recognized that blood cells re quire
continuous replenishment during postnata1life. Before him, the
assumption was that cells of the blood, like nerves once formed in
the embryo, remain in the body throughout life. Neumann also
recognized that this process occurred within the bone marrow,
because this tissue provided a fa vorable environment for
proliferation and differentiation of blood cell precursors. Vera
Danchakoff, the Russian embryologist working in the US, in 1916
made an analogy to the soil and the seed. Bone marrow forms the
soil, providing a favorable environment for the growth of seed, the
hemopoietic stem cell, and other progenitor cells. Imagine in the
remote past a heap of similar tree seeds. These seeds develop in
our moderate climate into a tall and many branched tree. Suppose
the wind bears a part of the seeds away and brings them to a land
possessing different environmental conditions, we will say the arc
tic lands. There the seeds may develop but they may pro duce trees
no higher than our moss."
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