Organic Synthesis, Fourth Edition, provides a reaction-based
approach to this important branch of organic chemistry. Updated and
accessible, this eagerly-awaited revision offers a comprehensive
foundation for graduate students coming from disparate backgrounds
and knowledge levels, to provide them with critical working
knowledge of basic reactions, stereochemistry and conformational
principles. This reliable resource uniquely incorporates molecular
modeling content, problems, and visualizations, and includes
reaction examples and homework problems drawn from the latest in
the current literature. In the Fourth Edition, the organization of
the book has been improved to better serve students and professors
and accommodate important updates in the field. The first chapter
reviews basic retrosynthesis, conformations and stereochemistry.
The next three chapters provide an introduction to and a review of
functional group exchange reactions; these are followed by chapters
reviewing protecting groups, oxidation and reduction reactions and
reagents, hydroboration, selectivity in reactions. A separate
chapter discusses strategies of organic synthesis, and he book then
delves deeper in teaching the reactions required to actually
complete a synthesis. Carbon-carbon bond formation reactions using
both nucleophilic carbon reactions are presented, and then
electrophilic carbon reactions, followed by pericyclic reactions
and radical and carbene reactions. The important organometallic
reactions have been consolidated into a single chapter. Finally,
the chapter on combinatorial chemistry has been removed from the
strategies chapter and placed in a separate chapter, along with
valuable and forward-looking content on green organic chemistry,
process chemistry and continuous flow chemistry. Throughout the
text, Organic Synthesis, Fourth Edition utilizes Spartan-generated
molecular models, class tested content, and useful pedagogical
features to aid student study and retention, including Chapter
Review Questions, and Homework Problems. A full Solutions Manual is
also available online for qualified instructors, to support
teaching.
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