Over the past ten years, there has been an increasing recognition
that syndromes of frontotemporal dysfunction (FTD) are a common
occurrence in patients with amyotrophic lateral sclerosis (ALS).
Such syndromes may be present in as many as 60% of patients with
ALS. Conversely, the occurrence of motor neuron dysfunction in
patients with clinically pure frontotemporal dementia is
increasingly recognized. This suggests that to some extent there
are overlapping syndromes in which both ALS and FTD occur within
the same individual. This volume summarizes the advances in our
understanding of these two disorders, as well as the potential
relationship between the two. Key topics include advances in our
ability to clinically describe the frontotemporal syndromes,
preclinical detection, neuroimaging, and genetics. The exploding
field of new markers in neuropathology is examined, as is the role
of new genetic mutations in DNA/RNA transport systems. This book is
the essential reference text for this topic, and will be of
interest to neurologists and neurological trainees with a clinical
or research interest in the FTDs or ALS, neuropsychologists,
neuropathologists, and researchers.
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