This book is intended to help decision-makers use, assess and
appraise the evidence that underpins decisions about the use of
therapeutic interventions. It will inform decision-makers about the
nature of evidence, the strengths and weaknesses of the available
approaches, and how these can be most effectively distilled for the
purpose of reaching reliable conclusions. It aims to encourage
decision-makers to base their judgements about the use of
therapeutic interventions on an informed appraisal of the totality
of the evidence base. Is it reliable? Is it generalisable beyond
the context of the environment in which the primary research has
been conducted? Do the intervention's benefits outweigh its harms?
Is it cost effective as well as clinically effective? Is it,
indeed, fit-for-purpose? Ultimately, good judgement is at the heart
of decision-making in therapeutics. An invaluable text for all
physicians, pharmacists, nurses, health commissioners and
purchasers and indeed anyone having to make decisions concerning
evidence-based therapeutics.
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