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Apatite - Synthesis, Structural Characterization and Biomedical Applications (Hardcover)
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Apatite - Synthesis, Structural Characterization and Biomedical Applications (Hardcover)
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Nanocrystalline apatites constitute the main inorganic part of
human hard tissues (bone and teeth), and a growing focus is devoted
to prepare synthetic analogs, so-called "biomimetic", able to
precisely mimic the morphological and physical-chemical features of
biological apatites. In fact, it is reasonable to hypothesize that
by virtue of their high similarity with the biogenic calcium
phosphates, synthetic nano-sized and ionic substituted apatite
nanocrystals can display better biological performances than
coarser and ceramic hydroxyapatite. For this reason, the study of
their crystallization mechanisms and the possibility to tailor the
structural and physical-chemical properties of these materials open
several possibilities to prepare optimal devices in medical
sciences and also to better investigate the biomineralization
processes of living organisms. This book is divided in three main
parts and is principally devoted to highlight the recent progresses
on the preparation and characterization of multifunctional
nanocrystalline apatites with tailored properties to be used as
healthcare materials (i.e. nanoparticles for drug or gene delivery
and materials for bone substitution and regeneration). The first
part is intended to be a comprehensive review of the importance and
the occurrence of calcium phosphates in nature (geological and
biological occurrence) and to underline the peculiar
characteristics of nanocrystalline apatites. The aim of the second
part is to show the most important analytical techniques for the
characterization of apatite features and to describe the new
theories behind the apatite crystallization and dissolution
processes. The last part describes the traditional and the most
exciting and innovative applications of pure, ionic-substituted,
and organic-functionalized apatite as biomaterial. The chapters,
written by eminent scientists, will serve as an important and
useful reference source for a broad audience that consists of both
expert (materials scientists, biomedical engineers and biologists)
and non-expert readers to who want to improve their knowledge in
the field of apatite based biomaterials.
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