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Books > Medicine > General issues > Medical equipment & techniques > Medical research
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Pancreatic Islet Isolation - From the Mouse to the Clinic (Hardcover, 1st ed. 2016)
Loot Price: R4,641
Discovery Miles 46 410
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Pancreatic Islet Isolation - From the Mouse to the Clinic (Hardcover, 1st ed. 2016)
Series: Advances in Experimental Medicine and Biology, 938
Expected to ship within 12 - 17 working days
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Pancreatic islets make up the endocrine pancreas and they contain
the only source of insulin in the body, beta cells. Hence, access
to high quality preparations of pancreatic islets is fundamental
for in vitro studies and to test pre-clinical applications in
animal models in vivo. Access to healthy human islets is also
crucial to improve transplantation procedures for diabetes. Given
the susceptibility of pancreatic islets to the enzymatic digestion
and mechanical stress required to obtain them, the isolation of
islets is often considered as the delicate "work of a craftsman".
This book, which is aimed at beginners and experts alike, is a
survey of the current state-of-the-art in this field and it centres
on the challenges, pitfalls and peculiarities of pancreatic islet
isolation in the different species used in pre-clinical and
clinical applications. It explores the similarities and differences
between human islets and those from other relevant species
(rodents, pigs and non-human primates), and how these influence
islet isolation. The ultimate goal of this book is to improve the
outcome of islet isolation and transplantation in pre-clinical and
clinical applications.
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