A comprehensive guide to the revolutionary area of systems
biology and its application in cell culture engineering, this
volume presents an overall picture of the current topics central to
structural and functional genomics, proteomics, metabolomics and
bioinformatics, including such hot topics as RNAi, metabolic
engineering and unfolded protein response. It includes reviews of
the cellular response of environmental modulation such as low
temperature and osmolarity, critical assessments of the
applications of metabolomics and fluxomics approaches, examination
of the utility of modulation of key genes and a presentation of a
theory of chemical organisation which provides a new view of the
system's structure. The clearly written chapters by experts in the
field describe methods applicable to investigating the unique
facets of cell culture. The book should be of interest to all those
working in cell culture development and drug discovery in
pharmaceutical and biotechnology companies as well as in academic
institutions. It provides an invaluable resource for students and
researchers in biotechnology, cell culture, genomics and
bioinformatics.
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