Molecular Characterization of Salmonella Paratyphi A from Bangladesh (Paperback)

Strains of Salmonella Paratyphi A isolated from the patients admitted to the diarrhoea treatment center of ICDDR, B were characterized both at the phenotypic and genotypic levels. Antibiotic susceptibility test revealed that 61% of the strains (n = 19) were sensitive to all the antibiotics used for empirical treatment of paratyphoid fever and 32% strains (n = 10) were resistant only to nalidixic acid. Most of the strains that showed reduced susceptibility to ciprofloxacin, having elevated MIC value (0.5ug/ml). A point mutation in the gyrA gene was observed at codon 83 (TCC to TTC), which substitutes phenylalanine for. This clearly indicates that a significant number of the S. Paratyphi A strains with reduced susceptibility to ciprofloxacin has been evolved. Of 31 strains, 16 (52%) of S. Paratyphi A strains harbored 35 MDa middle-ranged and non-conjugative plasmid. Pulse-field gel electrophoresis (PFGE) revealed that most of the strains (83%) were clonal regardless of antimicrobial sensitivity patterns.

General

Imprint:	VDM Verlag
Country of origin:	Germany
Release date:	August 2010
First published:	August 2010
Authors:	Muhammad Asaduzzaman • Nishat Nasrin
Dimensions:	229 x 152 x 7mm (L x W x T)
Format:	Paperback - Trade
Pages:	120
ISBN-13:	978-3-639-28858-2
Categories:	Books > Medicine > Clinical & internal medicine > Diseases & disorders > General
LSN:	3-639-28858-0
Barcode:	9783639288582

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