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Design and Development of Colon Targeted Drug Delivery System (Paperback)
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Design and Development of Colon Targeted Drug Delivery System (Paperback)
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The oral administration is the most convenient and commonly used
method for drug delivery. Traditionally, solid oral dosage forms
have been designed to release their drug load in the upper region
of the gastrointestinal tract, where conditions are more suited to
drug dissolutions and absorptions. Recently, greater emphasis has
been placed on controlling site of drug release from oral
formulations for the purposes of improving patient compliance and
treatment efficiency . Many protein and peptide drugs like insulin
cannot be administered through the oral route because of their
degradation by the digestive enzymes of the stomach and the small
intestine. Colon-specific drug delivery systems offer several
potential therapeutic advantages.The opportunity to reduce adverse
effects in the treatment of colonic diseases like, ulcerative
colitis, colorectal cancer, Chorn's diseases and amoebiasis by
topical application of drugs, active at the mucosal level The
elucidation of the mode of action of some nonsteroidal
anti-inflammatory drugs (NSAIDs) such as sulindac (metabolized in
the colon to the active moiety, sulindac sulfide) that were found
to interfere with the proliferation of co
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